![]() ![]() ![]() Hence, we have taken this review to discuss the various aspects of the NC cells.ĭelamination epithelial mesenchymal transition migration neural crest cells. Give rise to range of cell types: bone, connective tissue, endocrine cells, melanocytes, neurons, glial cells. Present along anterior/posterior length. Authors believe that a clear understanding of steps and signals involved in NC formation, migration, etc., may help in understanding the pathogenesis behind cancer metastasis and many other diseases. - Migrate from the dorsal neural tube to different sites in the embryo. Umpteen number of signaling molecules are essential for formation, epithelial mesenchymal transition, delamination, migration and localization of NCC. These migrating NCCs home in to different regions and give rise to plethora of tissues. Once formed, NC cells start migrating as a wave of cells, moving away from the neuroepithelium and quickly splitting into distinct streams. A few of the organs and tissues include peripheral and enteric (gastrointestinal) neurons and glia, pigment cells, cartilage and bone of the cranium and face, and smooth muscle. The non neural ectoderm, the neural plate and the underlying mesoderm are needed for the induction and formation of NC cells. The neural crest produces neural crest cells (NCCs), which become multiple different cell types and contribute to tissues and organs as an embryo develops. ![]() For these reasons, although derived from the ectoderm, the neural crest (NC) has been called the fourth germ layer. The neural crest cells (NCCs), a transient group of cells that emerges from the dorsal aspect of the neural tube during early vertebrate development has been a fascinating group of cells because of its multipotency, long range migration through embryo and its capacity to generate a prodigious number of differentiated cell types. ![]()
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